Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.

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Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients.

We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16...

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The highly polymorphic HRAS1 variable number of tandem repeats (VNTR), which maps 1 kb downstream from the human H-ras1 gene, has been described as an inherited predisposing factor in many human cancers. Here, we investigated the association between the presence of rare HRAS1 minisatellite alleles and lung cancer in the population studied. Four hundred sixty-six HRAS1 VNTR alleles from 233 lung...

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diversity of variable number tandem repeat loci in shigella species isolated from pediatric patients

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1992

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.9298187